Figure 3 (IMAGE)

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Figure 3

Caption

Hierarchical clustering of tonsil squamous cell carcinoma cohorts based on viral signature detection pattern with associated pathological features (perineural invasion (PNI), lymphovascular invasion (LVI), and tumor stage (T stage)). Hierarchical clustering for HPV16 (A) and HPV18 (B) viral probes are represented as heat maps for each cohort. Clustering was performed by R program using Euclidean distance, complete linkage and non-adjusted values. Clustering of the samples using NBClust software [Calinski and Harabasz index, Euclidean distance, complete linkage]. Chi-square test was applied and showed no significant differences of proportions of tumor stage (T1 versus T2), PNI, and LVI in different hierarchical clusters of cancer samples. NPR ("negative-node primary"), PPR ("positive-node primary"), NLN ("negative lymph node"), PLN ("positive lymph node"), CTRL ("control"), HPV (human papilloma virus), PNI (perineural invasion), LVI (lymphovascular invasion), T stage (tumor stage).

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Correspondence to - Erle S. Robertson - erle@pennmedicine.upenn.edu

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