Figure 7 (IMAGE)

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Figure 7

Caption

Schematic diagram of the molecular action of 2MeOE2. 2MeOE2 -mediated pro-apoptotic actions involve the catalytic activation of PKCδ by cellular caspases. The catalytic fragment of PKCδ is responsible for the apoptotic histone modifications in the nucleus and activates p38 MAPK pathway in the cytosol, which induces more activation of caspases that consequently cleave and activate more PKCδ. Therefore this cycle accelerates and amplifies the 2MeOE2-mediated apoptotic signal.

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Correspondence to - Dale Buchanan Hales - dhales@siumed.edu

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Copyright: © 2020 Pal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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