Figure 1 (IMAGE)
Caption
Figure 1: . (A) Confirmatory screen for hits using CAL27 and VU147 cells exposed to various repurposed drugs at Cmax (or lower), with and without cisplatin (n = 3). (B) Cell viability is compared to untreated controls following 72 (cell lines n = 3-7) or 96 (patient-derived primary tumor cells n = 6) hours exposure to quinacrine alone (black line) at increasing concentrations and also in the presence of cisplatin (red line). IC50 values are highlighted by vertical dotted lines color matched; responses fitted to a five-parameter logistic equation. (C) Viability of cells exposed to 1 μM quinacrine compared to untreated controls. (D) Summary of IC50 values (shaded columns) and inverse log of the IC50 values (pIC50) of quinacrine and standard error of the mean (SEM) in each cell line, with and without the addition of cisplatin.
Credit
Hisham Mehanna, email: h.mehanna@bham.ac.uk Nikolaos Batis, email: n.batis@bham.ac.uk
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