Figure 7 (IMAGE)
Caption
Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model. (A) APOBEC3B protein expression in H295R cells stably transfected with four different shRNAs targeting APOBEC3B. shRNA 2 and shRNA 4 were selected for in vivo experiments based on the efficiency. (B) Tumor growth curve in NOD scid gamma (NSG) mice that received a vector control, APOBEC3B shRNA2, and 4 stably transfected H295R cells flanks on either side. A total of eight mice per each group were used for this study. Three of the control mice died in the first week after injection for unrelated reasons. The error bars represent the standard error mean (SEM). *Indicates p < 0.05. (C) The tumor weight of each group at the time of sacrifice (8 weeks after xenograft). (D) The isolated tumors from each group at the time of sacrifice.
Credit
Correspondence to - Electron Kebebew - kebebew@stanford.edu
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