Figure 8 (IMAGE)

Impact Journals LLC

Figure 8

Caption

Model for biological function categorization of PMEPA1 isoforms (c, d and e) in the context of prostate cancer. Our study suggested a model where evaluation of PMEPA1 isoforms revealed a potentially new mechanism of prostate cancer cell adaptation from androgen dependent to hormone independent, TGF-β controlled cell growth. PMEPA1-e were androgen responsive whereas the PMEPA1 isoform c and d were TGF-β responsive and only isoform d inhibited TGF-β signaling.

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Correspondence to - Hua Li - hli@cpdr.org and Shashwat Sharad - ssharad@cpdr.org

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