Figure 8 (IMAGE) Impact Journals LLC Caption Model for biological function categorization of PMEPA1 isoforms (c, d and e) in the context of prostate cancer. Our study suggested a model where evaluation of PMEPA1 isoforms revealed a potentially new mechanism of prostate cancer cell adaptation from androgen dependent to hormone independent, TGF-β controlled cell growth. PMEPA1-e were androgen responsive whereas the PMEPA1 isoform c and d were TGF-β responsive and only isoform d inhibited TGF-β signaling. Credit Correspondence to - Hua Li - hli@cpdr.org and Shashwat Sharad - ssharad@cpdr.org Usage Restrictions CCBY License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.