Figure 4 (IMAGE)

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Figure 4

Caption

Exploratory biomarkers. (A) Total surviving cells count measured by flow cytometric analysis at H0, H2, H4 and H52 following treatment initiation. Drug infusion was started at H0. The horizontal bars represent median. (B) Percentage of γ-H2AX expression in surviving cells at H0, H2, H4 following treatment initiation. Groups were compared using Wilcoxon rank test. (C) Serum thymidine kinase 1 activity (Du/L) in dogs prior to treatment initiation (n = 48), at the time of the best clinical response (n = 36) and at the time of progressive disease (n = 30). Minimum detectable activity for this assay: 20 Du/L. The horizontal bars represent median. (D) Serum thymidine kinase 1 activity in dogs with complete (CR, n = 20) and partial (PR, n = 12) response. Minimum detectable activity for this assay: 20 Du/L. The horizontal bars represent median. Levels of sTK1 activity between groups were compared using Wilcoxon rank test. (E) Kaplan-Meier curve in dogs with high (> 0.5 mg/mL, n = 21) or low (? 0.5 mg/mL, n = 27) pretreatment D-dimer levels. Log-rank P value is shown.

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Correspondence to - Pierre Boyé, pierre_boye@hotmail.fr

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