Figure 1 (IMAGE) Impact Journals LLC Caption Chemical structure and kinase selectivity profiling of quizartinib, AC886, and other FLT3 inhibitors. (A) Chemical structures of midostaurin, gilteritinib, crenolanib, quizartinib, AC886, and sorafenib. (B) Binding affinity of compounds was measured against 404 nonmutant kinases. Kd values were calculated from duplicate 11-point dose-response curves. Each red circle represents a kinase bound to each compound. Larger circles indicate higher binding affinity of each compound to kinases. Kinases with Kd values <3000 nM are shown. Blue circles represent FLT3. Credit Correspondence to - Takeshi Isoyama - isoyama.takeshi.y5@daiichisankyo.co.jp Usage Restrictions CCBY License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.