Figure (IMAGE)
Caption
(A) Drastic target gene (RNA) suppression in the cerebral cortex when Blood-brain-barrier heteroduplex oligonucleotide (BBB-HDO) administered intravenously to mice. (B) RNA images in the cerebral cortex after administration of BBB-HDO to mice. The brown signal indicates RNA, but the signal is almost completely suppressed by BBB-HDO. (Scale: 100 μm). (C) Live image of mouse brain observed by in vivo confocal laser microscopy. The single-stranded antisense oligonucleotide (ASO) remains in the blood vessels of the brain, while the BBB-HDO is directly transferred into the brain.
Credit
Department of Neurology and Neurological Science,TMDU
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