Fluorescent Radiography Images (IMAGE) Johns Hopkins Medicine Caption Fluorescent radiography images of two wild type (WT, or normal) mice on top and two knockout (KO) mice on bottom. The KO mice are bred without a gene that produces a chaperone protein for protecting against immune activity on healthy cells. The presence of helper T cells and collagen is indicated by the green and orange signals, respectively. KO mice (bottom two images) show higher levels of collagen reactive helper T cells in the joints of the legs, indicating immune activity against collagen, a fibrous protein, and showing that collagen-induced arthritis, a mouse autoimmune disorder, has occurred. Credit Johns Hopkins Medicine Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.