Figure 9 (IMAGE)
Caption
Proposed schema of AZ, SFN, and AZ+SFN targeting the pro-survival pathways in BC. (A) BC cells are in an acidic environment under normal conditions, supporting: (1) growth factor stimulation; and (2) activation of the glycolytic pathway and migratory/invasive potential. (B) AZ+SFN treatment works to: (1) modulate the antioxidant response; (2) decrease 5-HT secretion; and (3) decrease hypoxia, making the cell intracellularly more acidic and the extracellular environment more alkaline. The pan-inhibition of these pathways and critical components can ultimately reduce or abrogate BC cells' tumorigenic potential. The question marks in B require further evidence and study. The images were created with https://biorender.com. Abbreviations: AZ: acetazolamide; SFN: sulforaphane; BC: bronchial carcinoma.
Credit
Correspondence to - Herman Yeger - hermie@sickkids.ca, Reza Bayat Mokhtari - rbm7@queensu.ca, and Myron R. Szewczuk - szewczuk@queensu.ca
Usage Restrictions
Credit must be given to the creator.
License
CC BY