Figure Abstract (IMAGE)
Caption
A series of amines, including synthetic challenging primary amines were synthesized with highly tolerance of other reducible functional groups. Mechanistic studies from control experiments and cross-coupling reactions via NMR spectroscopy, operando IR as well as DFT computation reveal a distinct reaction pathway involving aldehyde and amido complex as intermediates. Thus, the current protocol represents a new amide bond activation model that involves C-N bond cleavage-reforming and C-O bond cleavage process.
Credit
Chinese Journal of Catalysis
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