Activity of GPi cells in response to electrical stimulation of the cerebral cortex. (IMAGE)
Caption
In healthy condition (left), well-balanced early excitation, inhibition, and late excitation are observed. However, in Parkinson’s disease (center), inhibition that through the “direct pathway” is lost. Drug therapy (left) and surgical treatment (right) relived Parkinson’s disease symptoms and recovered inhibition. The results suggest that disturbance of information flow through the direct pathway, which operates to initiate movements, causes difficulty in initiating movements in Parkinson’s disease, and restoration of the information flow through the direct pathway is the key to treat Parkinson’s disease.
Credit
Atsushi Nambu
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