Kleefstra syndrome (IMAGE) RIKEN Caption Kleefstra syndrome is associated with reduced H9K3 methylation in the brain, which leads to intellectual disability. The new study found greater microglia activation and neuroinflammation in a mouse model of the disease. Neural and behavioral symptoms were reduced when GLP was provided after birth. Credit RIKEN Usage Restrictions credit RIKEN License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.