Aerobic exercise ameliorates doxorubicin-induced cardiotoxicity (IMAGE) Impact Journals LLC Caption Figure 6: Aerobic exercise ameliorates doxorubicin-induced cardiotoxicity. Average distance ran per 24-hour period ± SEM in female, retired breeder BALB/c mice (A). Black arrows denote injections of PBS or DOXO on days 19, 22, and 25 after initial randomization (total dose 18 mg/kg). Heart mass to tibia length ratio (mg/mm; (B)). Circulating levels of cardiac troponin I, n = 5 per group (pg/mL; (C)). Soleus mass (mg; (D)). Linear regression of individual average soleus mass and normalized heart mass, Pearson's R2 values denoted in panel (E). Two-way ANOVA was used to statistically compare means between groups with Tukey's post-hoc analysis, detailed analysis in Supplementary Figure 4, p values denoted in panels (p* ≤ 0.05), study sample size: NWR PBS n = 8; EX PBS n = 8; NWR DOXO n = 9; EX DOXO n = 9. Credit Correspondence to - Zachary R. Wakefield - email@example.com Usage Restrictions Credit must be given to the creator. License CC BY Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.