Janus kinase (IMAGE)

Howard Hughes Medical Institute

Janus kinase

Caption

When a cytokine (green) binds to receptors (teal), two parts of the Janus kinase protein (pink) come together, activating it to send signals inside a cell. In some cancers, mutations in the kinase lock it together, keeping it abnormally active.

Credit

Eric Smith/Chris Garcia/Howard Hughes Medical Institute

Usage Restrictions

Must use with credit

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.