Sup35 Sequestration Polyglutamine Aggresome (IMAGE) Georgia Institute of Technology Caption This is an image showing sequestration of the prion form of translation release factor Sup35 (red) by polyglutamines in an aggresome (green). A new study found that aggresome formation in yeast cells containing Sup35 did not reduce the toxicity of huntingtin proteins with a polyglutamine tract. The study suggests a potentially new approach for identifying possible therapeutic targets for treating Huntington’s disease. Credit Georgia Tech/Yury Chernoff Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.