Sup35 Sequestration Polyglutamine Aggresome (IMAGE)

Georgia Institute of Technology

Sup35 Sequestration Polyglutamine Aggresome

Caption

This is an image showing sequestration of the prion form of translation release factor Sup35 (red) by polyglutamines in an aggresome (green). A new study found that aggresome formation in yeast cells containing Sup35 did not reduce the toxicity of huntingtin proteins with a polyglutamine tract. The study suggests a potentially new approach for identifying possible therapeutic targets for treating Huntington’s disease.

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Georgia Tech/Yury Chernoff

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