MMP-2 Leptin Clipping Mechanism (IMAGE)

University of California - San Diego

MMP-2 Leptin Clipping Mechanism

Caption

Mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This blocks leptin from binding to its receptors. This in turn keeps the neurons from signaling that your stomach is full and you should stop eating.

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University of California San Diego

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