Oncogenic lncRNA FAL1 (IMAGE)

University of Pennsylvania School of Medicine

Oncogenic lncRNA FAL1

Caption

This image depicts an oncogenic lncRNA FAL1 (the dragon) dysregulating gene transcription and promoting tumorigenesis. FAL1 stabilizes BMI1 (the stone) by associating with it (the dragon twine around the stone), which subsequently enhances the activity of PRC1 (the stone pile). Constant information flow from DNA to mRNA (the water stream) is essential for normal cell growth. Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus-like eremophytes instead of normal plants from the drought).

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Artwork by Lili Guo

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