Decoding DNA Finds Breast Tumor Signatures that Predict Treatment Response (IMAGE)

WashU Medicine

Decoding DNA Finds Breast Tumor Signatures that Predict Treatment Response

Caption

Decoding the DNA of women with advanced breast cancer has allowed scientists to identify distinct cancer "signatures" that could help predict which patients are most likely to benefit from estrogen-lowering therapy, often prescribed to shrink large tumors before surgery. Compared to women who responded to the drugs, those who didn't had tumors that were genomically more unstable, with higher rates of mutations and other changes. Above, a circos plot of tumor DNA from a patient who didn't respond to the drugs.

Credit

The Genome Institute at Washington University in St. Louis.

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Credit to The Genome Institute at Washington University in St. Louis.

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