Day and Night (IMAGE)
Caption
Schematic of Rev-erb's role in gene expression. At night (left), when Rev-erb concentration decreases, gene expression is turned on by protein complexes that loop the chromosome bringing together distant regions (blue and pink). During the day (right), when Rev-erb levels rise, the protein complexes are kicked out, causing the loop to loosen and turn off gene expression.
Credit
Yong Kim and Mitch Lazar, Perelman School of Medicine, University of Pennsylvania
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