An Ultrathin Collagen Matrix Assembly (IMAGE)

World Scientific

An Ultrathin Collagen Matrix Assembly

Caption

This is an ultrathin collagen matrix assembly maintained the morphology and function of primary liver hepatocytes in a microfluidic organ-on-a-chip device for two weeks. Three images of the hepatocytes after two weeks in a microfluidic device: A phase contrast image of cell morphology at two weeks showing dense cytoplasm, distinct nuclei, and bright cell borders; bile canalicular network development (red); and cell nuclei (blue) and actin (green) organization demonstrating cell polarity. Scale bar: 50 microns.

Credit

Credit: William McCarty, the Center for Engineering in Medicine at the Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children-Boston.

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