A Synthetic Method (IMAGE)

_Tokyo Medical and Dental University

A Synthetic Method

Caption

The Mukaiyama aldol reaction of 6-(triflyloxy)benzocyclobutenones with ketene silyl acetals and subsequent generation of γ-aryl-β-ketoester-type arynes from resulting 6-(triflyloxy)benzocyclobutenols in the presence of arynophiles efficiently provided a wide range of γ-aryl-β-ketoesters. The method was applicable to the synthesis of an analog of ALK inhibitor.

Credit

Department of Chemical Bioscience,TMDU

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