B Cells and Germinal Centers (IMAGE)

Helmholtz Association

B Cells and Germinal Centers

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In germinal centers (here: whithin the spleen of a mouse) immune cells learn to fight pathogens with high specificity. Dr. Dinis Calado and Dr. Klaus Rajewsky of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, now identified subpopulations of B cells at the germinal centers which express the proto-oncogene Myc (red). They showed that Myc is essential for the formation and maintenance of germinal centers. Their findings have implications for the pathogenesis of B-cell lymphomas (Nature Immunology, DOI:10.1038/ni.2418).

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Photo: Dinis Calado/Copyright: MDC

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