Combination Therapy/Boosting PARP Inhibitors (IMAGE)

University of Maryland School of Medicine

Combination Therapy/Boosting PARP Inhibitors

Caption

The goal of the therapy is to cause the protein PARP to be trapped longer at the site of DNA damage within a cancer cell. Microscopic images show a damaged breast cancer cell treated with either a PARP inhibitor or a DNMT inhibitor (left) and one treated with both agents (right). PARP (in yellow) at the damage site prevents the cell from repairing itself, causing it to die.  

Credit

Johns Hopkins Kimmel Cancer Center

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