Prototype Drug Blocks MCL-1 Protein that Helps Cancer Tumors Survive Treatment (IMAGE)
Caption
By leveraging nature's solution to ligand selectivity, Stewart et al. developed a selective inhibitor of anti-apoptotic MCL-1, which has emerged as a formidable survival factor for a wide variety of cancers. By screening a panel of stapled peptide helices of BCL-2 family protein interaction domains, the team discovered that, ironically, MCL-1's own BH3 death domain helix is a uniquely exclusive MCL-1 inhibitor that resensitizes cancer cells to select apoptotic stimuli that are especially blunted by MCL-1 expression.
Credit
Dana-Farber Cancer Institute
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