A Schematic Showing Gip1 Sequestration of G Proteins in the Cytosol (IMAGE)

The University of Osaka

A Schematic Showing Gip1 Sequestration of G Proteins in the Cytosol

Caption

G proteins typically attach to the surface of the plasma membrane by anchoring their hydrophobic lipid-attached region into the membrane. However, Gip1 interacts with and masks this lipid-attached region of G proteins, so that G proteins are sequestered in the cytosol. Upon receiving signals from GPCR proteins, the size of the Gip1 binding cavity is reduced, which allows release of G proteins.

Credit

Masahiro Ueda/Osaka University

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.