Chromosome Separation (IMAGE)
Caption
When the kinetochore-attached microtubules are from opposite sides of the cell and are pulling in opposite direction they generate tension that causes a protein molecule, Stu2, to stabilize the connection. See the model of correct positionin, above. If, however, the kinetochores become attached to two microtubules from the same side of the cell, they more or less in the same direction and generate less tension. Stu2 acts to destabilize the attachment. This allows the connection to break and gives the kinetochore another chance to establish a correct connection with the microtubules. See the incorrect position, above.
Credit
Charles Asbury/University of Washington
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