TIMP-1 and TIMP-4 in Liposarcomas (IMAGE) Hiroshima University Caption TIMP-4 prevents YAP/TAZ from entering the tumor cell nucleus. It is then stored in the cytoplasm and degraded. TIMP-1 activates YAP/TAZ and leads to cell proliferation. Credit Toshinori Ando/University of Hiroshima Usage Restrictions Image may be reused only with attribution to Hiroshima University. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.