GABA-B transition (VIDEO)

DOE/SLAC National Accelerator Laboratory

Caption

The activation transition for the GABAB receptor. GABAB comprises two distinct parts, GB1 and GB2. In the first step toward activation, researchers added an agonist, a GABA-like molecule that brings the pieces of GB1 and GB2 that sit outside the cell together. In the second step, the team added a molecule called a positive allosteric modulator, or PAM, which together with the agonist stabilized GABAB in its active form.

Credit

Video courtesy Cornelius Gati/SLAC National Accelerator Laboratory

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