GABA-B transition (VIDEO) DOE/SLAC National Accelerator Laboratory This video is under embargo. Please login to access this video. To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Caption The activation transition for the GABAB receptor. GABAB comprises two distinct parts, GB1 and GB2. In the first step toward activation, researchers added an agonist, a GABA-like molecule that brings the pieces of GB1 and GB2 that sit outside the cell together. In the second step, the team added a molecule called a positive allosteric modulator, or PAM, which together with the agonist stabilized GABAB in its active form. Credit Video courtesy Cornelius Gati/SLAC National Accelerator Laboratory Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.