A New Mouse Model of Neurodegeneration (IMAGE)

NIH/National Institute of Neurological Disorders and Stroke

A New Mouse Model of Neurodegeneration

Caption

This image compares sections of cortex from a control mouse (left) to a mouse with a presenilin-1 mutation (right). The dashed line indicates the surface of the brain. Presenilin-1 mutations decrease gamma-secretase activity and cause features of neurodegeneration, including shrinkage of the cortex, as shown above.

Credit

Image courtesy of Raymond Kelleher and Jie Shen, Harvard Medical School.

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