TDP-43 simulation (IMAGE) Lehigh University Caption A snapshot of the TDP-43 simulation highlighting the formation of oligomers mediated by helix-helix contacts (magenta). (A. E. Conicella, G. L. Dignon, G. H. Zerze, H. B. Schmidt, A. M. D'Ordine, Y. C. Kim, R. Rohatgi, Y. M. Ayala, J. Mittal, N. L. Fawzi. TDP-43 &alpha;-helical structure tunes liquid-liquid phase separation and function. Proceedings of the National Academy of Sciences 117, 5883-5894 (2020). DOI: 10.1073/pnas.1912055117) Credit Figure reproduced with permission from Proceedings of the National Academy of Sciences USA. Usage Restrictions Contextual, credited use only. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.