Longevity Protein SIRT6 also Protects against Fatty Liver and Fatty Liver Disease (IMAGE)
Caption
Researchers at Bar-Ilan University reveal in a new study published in Cell Reports that the longevity protein SIRT6, which regulates many biological processes such as aging, obesity, insulin resistance, inflammation and metabolism, also plays a crucial role in burning and regulating liver fat metabolism. By activating and working together with the protein PPAR-alpha, SIRT6 can actually send a message to the body to burn more fat. This cooperation is one way in which SIRT6 protects against fatty liver and fatty liver disease, as well as obesity-related damage. In this image the researchers show that SIRT6 activates PPAR-alpha to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.
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Avia Cohen
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