Figure 1 (IMAGE)

Columbia University School of Engineering and Applied Science

Figure 1

Caption

This figure shows that there is substantially more cleavage of Remdesivir-RNA (g, h, i) than Sofosbuvir-RNA (a, b, c) by SARS-CoV-2 exonuclease. It is also apparent that Remdesivir-RNA (g, h, i) is cleaved by the exonuclease more rapidly than RNA extended with UMP (d, e, f). The results were obtained by treatment of the RNA products with the SARS-CoV-2 exonuclease proofreader and analysis by MALDI-TOF mass spectrometry to determine relative excision of Sofosbuvir, UMP, and Remdesivir.

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Jingyue Ju/Columbia Engineering

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