UNC Researchers Engineer 'Protein Switch' to Dissect Role of Cancer's Key Players (IMAGE)

University of North Carolina Health Care

UNC Researchers Engineer 'Protein Switch' to Dissect Role of Cancer's Key Players

Caption

At top is a structural model of uniRapR domain which binds small molecule rapamycin. The bottom left depicts inactive state of the protein of interest modified with uniRapR domain. Binding of rapamycin and uniRapR reactivates the protein (bottom right).

Credit

Dokholyan Lab, UNC School of Medicine

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