Mutagenesis Model of Molnupiravir (IMAGE)
Caption
Mutagenesis Model of Molnupiravir. SARS-CoV-2 polymerase (oval) mediated nucleotide incorporation into the RNA primer (grey circles)/template (white circles). Plus and minus sense indicate RNA sense. A, C, G, and U refer to natural nucleotide bases and M refers to the active forms of molnupiravir. Three small circles indicate the triphosphate form of nucleotides. (1) Molnupiravir competes with CTP for incorporation during synthesis of the negative RNA strand (copy of the genome). (2) When embedded in the template, molnupiravir base-pairs with either ATP or GTP. (3) Incorporation of ATP results in mutagenesis. (4) The mutation is fixed as RNA synthesis continues. The boxed information provides a summary of events that lead to drug-induced G to A and C to U transition mutations.
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Supplied by Matthias Gotte
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