Rat Nucleus Accumbens (IMAGE)

Society for Neuroscience

Rat Nucleus Accumbens

Caption

CRISPR activation enables flexible upregulation of selected genes in cultured neurons and the adult nervous system. Here, neurons in the rat nucleus accumbens (a key brain reward structure) were targeted for CRISPR-based gene activation. Fluorescent reporter molecules mark the protein product of a gene targeted for activation (green), neurons expressing a CRISPR guide RNA (red), and DNA (blue).

Credit

Katherine Savell & Nancy Carullo, Day Lab, University of Alabama at Birmingham

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