A Spine-Autonomous BDNF-TrkB Signalling Loop Critical for Synaptic Plasticity (VIDEO)

Max Planck Florida Institute for Neuroscience

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Researchers identified an autocrine signaling system within single dendritic spines. This autocrine signaling system is achieved by rapid release of the protein, BDNF, from a stimulated spine and subsequent activation of its receptor, TrkB, on the same spine, which further activates signaling inside the spine.

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Max Planck Florida Institute for Neuroscience

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