Time-Keeping Brain Protein Influences Memory (IMAGE)
Caption
The core clock regulates distinct behaviors via discrete PDF targets: a proposed model. Localization of PDFR to the clock permits control of locomotor activity independently from control of memory. Signaling through PDFR in a population of interneurons extrinsic to both the clock and mushroom bodies (here shown as IN1) permits regulation of appetitive memory. We propose that, in place of PDF-PDFR signaling, PDF activation of a novel unidentified receptor (here called PDFR2) in a separate population of interneurons (IN2) is required for aversive memory.
Credit
Flyer-Adams et al., JNeurosci 2020
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