Clock Gene Disruption (IMAGE)
Caption
Daily variation in blood pressure in normal mice versus mice in which clock genes have been disrupted. In mice with normal clock protein (BMAL) function, blood pressure rises during the morning hours (left). In BMAL knockout mice, the daily variation in blood pressure vanishes (right).
Credit
Annie M. Curtis, Ph.D., and Garret A. FitzGerald, M.D., University of Pennsylvania School of Medicine; Proceedings of the National Academy of Sciences
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