Cancer (IMAGE)
Caption
A schematic of the study results show stochastic (random) gains in DNA methylation at CpG sites (black circles) occur in developmental regulator genes during tumorigenesis or normal aging compared to programmatic methylation gains in metabolic regulators during senescence. Senescence is a state of permanent arrest from which the cells cannot be transformed. Each line of circles depict the methylation (black circle) or no methylation (white circle) in independent cells.
Credit
<i>Cancer Cell</i>
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