Modification of the Viral Protein Coat by MELK Regulates its Removal to Allow Viral DNA Synthesis (IMAGE)

_Tokyo Medical and Dental University

Modification of the Viral Protein Coat by MELK Regulates its Removal to Allow Viral DNA Synthesis

Caption

Shortly after HIV-1 entry, MELK produced by the target cell regulates removal of the protein coat (the capsid, CA, which is an important part of the core of the virus) by adding a modification at a specific location. This regulated coat removal promotes optimal production of viral DNA, allowing the infection process to proceed efficiently.

Credit

Department of Molecular Virology,TMDU

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