Inhibition of SUMO E1 Activating Enzyme by the Allosteric Inhibitor COH000 (VIDEO)

Medical University of South Carolina

Caption

This movie depicts the conformational changes that accompany SUMO E1 binding to COH000. Selected structural elements are labeled and regions of the enzyme that become disordered in the SUMO E1/COH000 complex transition from solid to transparent representations.

Credit

Medical University of South Carolina, courtesy of Dr. Shaun Olsen

Usage Restrictions

Use with appropriate title and credit line

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.