Multi-nucleotide Mutation (IMAGE)

Indiana University

Multi-nucleotide Mutation

Caption

If mutations only happened one-at-a-time, three separate mutation events would be required to convert ACT to GGA (top). Multi-nucleotide mutation, facilitated by error-prone polymerases, can allow for 2 to 9 simultaneous mutations, opening up whole new considerations for protein evolution.

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Image by Dan Schrider

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