ESAM Deficiency (IMAGE)

The University of Osaka

ESAM Deficiency

Caption

ESAM deficiency causes high fetal mortality and decreased expression of Alas2, and adult-type globin genes in ESAM-null HSCs impairs development of adult-type erythropoiesis. This shows the contribution of ESAM to the ontogeny of definitive hematopoiesis and the functional involvement of ESAM-expressing endothelial cells.

Credit

Osaka University

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