ESAM Deficiency (IMAGE) Osaka University Caption ESAM deficiency causes high fetal mortality and decreased expression of Alas2, and adult-type globin genes in ESAM-null HSCs impairs development of adult-type erythropoiesis. This shows the contribution of ESAM to the ontogeny of definitive hematopoiesis and the functional involvement of ESAM-expressing endothelial cells. Credit Osaka University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.