Figure: Outline of the Study (IMAGE) Kanazawa University Caption Vesamicol derivatives, in which alkyl chains of varying chain lengths were introduced between a piperazine ring and a benzene ring, were synthesized and evaluated. Screening of the binding affinity of these vesamicol derivatives for the sigma-1 receptor was performed. The radioiodine labeled probe [I-125]2-(4-(3-(4-iodophenyl)propyl)piperazin-1-yl)cyclohexan-1-ol was prepared and evaluated in in vitro and in vivo. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.