SARS-CoV-2 Replication Transcription Complex (IMAGE) DOE/Oak Ridge National Laboratory Caption To study the SARS-CoV-2 replication transcription complex, the team built an integrated workflow that models the experimental Cryo-EM volumetric data as a finite element mesh. This mesh is then simulated using fluctuating finite element analysis (FFEA). To annotate the mesh with the strengths of the protein-protein interactions, the researchers used all-atom molecular dynamics (AAMD) simulations and employed AI-techniques to automatically bridge the FFEA and AAMD simulations. Credit Defne Gorgun, Anda Trifan, and Arvind Ramanathan Usage Restrictions N/A License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.