VP1-2's Role In Suppressing Immunity (IMAGE) Rockefeller University Press Caption Herpes simplex virus (HSV1) replication in brain slices was strongly impaired in the absence of its VP1-2 protein's de-ubiquitination activity (ΔDUB, bottom row), as shown here by the reduced number of virus-producing cells (black). This highlights VP1-2's role in suppressing immunity. Credit Bodda et al. 2020 Usage Restrictions Reporters may freely use these materials in news coverage, with the appropriate credit information. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.