Figure: Scheme for Intraspecies Molecular Evolutionary Analysis (IMAGE)

The University of Osaka

Figure: Scheme for Intraspecies Molecular Evolutionary Analysis

Caption

A. Random genetic drift induces synonymous and nonsynonymous mutations with equal probability. However, nonsynonymous mutations in essential regions are subjected to selective pressures. B. As a result of natural selection, synonymous substitutions are concentrated in important genes. Phylogenetic and molecular evolutionary analyses can detect significant accumulation of synonymous substitutions in codons of host proteins. Codon-based analysis yields much more information than nucleotide- or amino acid-based analyses.

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©2019 Yamaguchi M. <i>et al., Communications Biology</i>

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