Two Ways Neuroblastoma Takes out let-7 (IMAGE)

Boston Children's Hospital

Two Ways Neuroblastoma Takes out let-7

Caption

This Venn diagram shows that most patients with neuroblastoma lose let-7 through a single mechanism, but rarely both together. In about 25 percent of patients, the oncogene MYCN is amplified, whereas most of the rest lose let-7 through a chromosomal deletion of the 11q and/or 3p regions. A very small number of patients have overlapping tumor-promoting mechanisms, suggesting that once a cancer develops one anti-let-7 strategy, it has little need for a second one.

Credit

Courtesy John Powers, PhD

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.