Engineering Antibody Sugar Groups (IMAGE)

University of Maryland

Engineering Antibody Sugar Groups

Caption

Antibodies with identical protein structures (Y-shaped center structures) often have naturally occurring differences in their attached sugar groups (left, inside green ovals). These differences result in enhanced or suppressed abilities to activate the immune response. A process designed at the University of Maryland and tested with help from Rockefeller University allows the engineering of antibodies with identical sugar groups (right, inside pink ovals), which can standardize the activity of the antibodies.

Credit

Tiezheng Li/Lai-Xi Wang/UMD

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